Apicidin
HDAC inhibitor / Apicidin is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC’s).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase.2 Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.3
Biochemicals & reagents
183506-66-3
1) Darkin-Rattray, et al. (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase Proc.Nat.Acad.Sci. USA 93 13143 / 2) Han, et al. (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin Cancer Res. 60 6068 / 3) Kim, et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases Oncol. Rep. 17 647
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TARGET: Protein deacetylase -- PATHWAY: Chromatin; Cell cycle; Posttranslational modification; Autophagy; Transcription -- RESEARCH AREA: Epigenetics; Oxidative stress; Cell death; Stem cells -- DISEASE AREA: Cancer; Infectious disease