U-18666A
Cholesterol transport inhibitor / U18666A is an oxidosqualene reductase inhibitor.1 Inhibits the egress of cholesterol from late endosomes and lysosomes.2 Also used to study Niemann-Pick disease and for assessing the importance of molecular trafficking through the lysosomal pathway in other conditions.3
Biochemicals & reagents
3039-71-2
1) Sexton et al (1983) Effects of 3.beta.-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures. Biochemistry 22 5687 / 2) Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 / 3) Cenedella, (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes: Lipids 44, 477
RT
TARGET: Lysosome -- PATHWAY: Cholesterol metabolism; Intracellular transport; Calcium signaling -- RESEARCH AREA: Vesicles -- DISEASE AREA: Diabetes; Infectious disease