Chloroquine phosphate
Autophagy inhibitor / Antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer2. Eliminates cancer stem cells via deregulation of Jak2 and DNMT13. Displays synergy when combined with the Raf inhibitor, vemurafenib, in brain tumor4. Cell permeable and active in vivo.
Biochemicals & reagents
50-63-5
1) Frieboes et al. (2014), chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy; JOP, 15 189 2) Jiang et al. (2010), Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer; Biomed. Pharmacother., 64 609 3) Choi et al. (2014), Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1; Stem Cells, 32 2309. 4) Mulcahy Levy et al. (2014), Autophagy inhibition improves chemosensitivity in BRAFV600E brain tumors; Cancer Discov., 4 773
RT
PATHWAY: Autophagy; JAK/STAT; Intracellular transport; Cytokine -- RESEARCH AREA: Cancer Stem Cells; Cell death; Immunology -- DISEASE AREA: Cancer; ParasitesInflammation; Infectious disease