R-Spondin 1, human recombinant
R-Spondin 1 (RSPO-1) is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling. R-Spondin 1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification. R-Spondin 1 is suggested to function as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis. Additionally, recombinant R-spondin 1 protein is used to initiate and maintain intestinal organoid cultures.
Peptides & proteins
RSPO-1, RSPO 1, hRspo1, Roof plate-specific spondin-1
at -20°C
at least 12 months
NAME: R-Spondin 1; ACCESSION/UNIPROT#: Q2MKA7; EXPRESSION SYSTEM: CHO; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing phosphate buffered saline (PBS). Reconstitute in sterile water at 0.1 mg/mL.; #AA: 243; SEQUENCE: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA