PODS® Human Ephrin-A3

PODS® Human Ephrin-A3 contains the polyhedrin protein co-crystalized with Human Ephrin-A3. Ephrin-A3 is a member of Ephrin-A famil, and it is also known as EHK1-L, EFL-2, and LERK-3. Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Ephrin-A3 expression can be up- or down-regulated by hypoxia in the hippocampus or vascular endothelial cells, respectively. Ephrin-A3 interaction with EphA receptors induces neurite growth cone collapse and the repulsion of migrating axons, which is important for the accurate migration of axons during CNS development.