IL-17A/F, rat recombinant
Heterodimeric interleukin-17A/F is a member of the IL-17 family of six homodimeric proteins (IL-17A-17F). Recent IL-17A/IL-17F co-expression studies in HEK-293 cells revealed the presence of a biologically active heterodimer, IL-17A/F. Activated CD4+ T cells have also been shown to produce human IL-17A/F. Activity studies reveal hIL-17A to be the most potent, followed by hIL-17A/F and hIL-17F 100 fold lower than hIL-17A. IL-17A/F is thought to induce neutrophilia and chemokine expression via the IL-17RA receptor.Recombinant rat IL-17A/F produced in E.coli is a heterodimeric non-glycosylated polypeptide comprised of one monomeric subunit each of r-IL-17A and r-IL-17F.
Peptides & proteins
at -20°C
at least 12 months
NAME: Interleukin-17AF Heterodimer; ACCESSION/UNIPROT#: Q61453/Q5BJ95; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; #AA: 268; SEQUENCE: IL-17A: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS IL-17F:MARRNPKVGL SALQKAGNCP PLEDNSVRVD IRIFNQNQGI SVPRDFQNRS SSPWD YNITR DPDRFPSEIA EAQCRHSGCI NAQGQEDGSM NSVPIQQEIL VLRREPQGCS NSFRLEKMLI KVGCTCVTPI VHHAA