TNF-alpha, mouse recombinant
Tumor Necrosis Factor alpha (TNF-alpha) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, NK-cells following their stimulation by bacterial LPS. TNF-alpha activates signals through two receptors: TNF-R1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells. TNF-alpha can have many functions including to stimulate of phagocytosis in macrophages, to chemoattract neutrophils, to increase insulin resistance and to induce fever. Recombinant mouse TNF-alpha is a non-glycosylated protein.
Peptides & proteins
TNFSF2, Cachectin, DIF, Necrosin, Cytotoxin, Cachexin, TNF
-20°C
NAME: Tumor Necrosis Factor alpha; ACCESSION/UNIPROT#: P06804; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: cytolysis of mouse L929 cells in the presence of Actinomycin D with an acceptance criteria of 100 pg/mL (ED50), 1 x 10^7 units/mg.; #AA: 157; SEQUENCE: MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL