IFN-gamma, mouse recombinant
The major interferon is produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease. IFN-gamma is produced mainly by T-cells and natural killer cells activated by antigens, mitogens, or alloantigens. It is produced by lymphocytes expressing the surface antigens CD4 and CD8. The synthesis of IFN-gamma is induced, among other things, by IL-2, FGF-2, and EGF. Recombinant Murine IFN-gamma is a single, non-glycosylated, polypeptide chain.
Peptides & proteins
Type II interferon, T cell interferon, Immune Interferon, MAF
-20°C
NAME: Interferon gamma; ACCESSION/UNIPROT#: P01580; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: Viral CPE assay using EMC virus on L929 cells with an acceptance criteria of 1 x 10^7 units/mg.; #AA: 134; SEQUENCE: MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC