GM-CSF, mouse recombinant
Mouse GM-CSF is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. GM-CSF receptors shows significant homologies with other receptors for hematopoietic growth factors, including IL-2 beta, IL-3, IL-6, IL-7, EPO and the Prolactin receptors. Recombinant mouse GM-CSF is a single, non-glycosylated, polypeptide chain.
Peptides & proteins
CSF-2. Pluripoietin-α, MGI1GM
at -20°C
at least 12 months
NAME: Granulocyte Macrophage-Colony Stimulating Factor; ACCESSION/UNIPROT#: P01587; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM acetic acid . Reconstitute in sterile water at 0.1 mg/mL.; TESTING: FDCP-1 cell proliferation with an acceptance criteria of 50 pg/mL (ED50), 2 x 10^7 units/mg.; #AA: 125; SEQUENCE: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK