NGF-β, mouse recombinant
Nerve Growth Factor (NGF) is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity. The synthesis of NGF in astrocytes is enhanced by various other cytokines: IL-1, TNF-alpha, PDGF and TGF beta. Mouse NGF-beta is non-glycosylated, non-covalently linked homodimer.
Peptides & proteins
beta-NGF
-20°C
NAME: Nerve Growth Factor beta; ACCESSION/UNIPROT#: Q6LDU8; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; TESTING: TF-1 cell proliferation with an acceptance criteria of 5 ng/mL (ED50), 2.0 x 10^5 units/mg.; #AA: 242; SEQUENCE: MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G