IL-21 (animal free), human recombinant
Interleukin-21 (IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15. Its private receptor, IL-21R, is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. IL- 21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. Recombinant Human IL-21 is a single, non-glycosilated polypeptide chain. Animal Free: This product is produced with no animal-derived raw products, animal free equipment and animal free protocols.
Peptides & proteins
-20°C
Produced using animal free raw components and processes, in a non-mammalian system. Ideal for researchers concerned about the risks and effects of contaminating viruses, prions and trace growth factors from FBS and animal-derived ingredients used in standard recombinant protein production techniques. Endotoxin levels are less than 1.0 EU per ug protein via LAL. Bioactivity is comparable to recombinant protein produced in traditional techniques.