FGF-1, human recombinant
FGF-1 is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. It binds to heparin, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF (keratinocyte growth factor = FGF-7). All factors are products of different genes, some of which are Oncogene products (FGF-3, FGF-4, FGF-5). Recombinant Human FGF-1 is a single, non-glycosylated, polypeptide chain.
Peptides & proteins
FGF1, HBGF-1, Beta-endothelial growth factor, ECGF-beta
at -20°C
at least 12 months
NAME: Fibroblast Growth Factor acidic ; ACCESSION/UNIPROT#: P05230; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 75 mM sodium chloride, pH 7.5 . Reconstitute in sterile water at 0.1 mg/mL.; TESTING: BALB/c 3T3 cell proliferation with an acceptance criteria of 2 ng/mL (ED50), 5.0 x 10^5 units/mg.; #AA: 141; SEQUENCE: MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D