GDNF, human recombinant
Glial-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that is closely related to other neurotrophic factors, such as neurturin, persephin, and artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes RET and GFRα1-4, to romote dopamine uptake, survival and differentiation of neurons. Recombinant human GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains and with a total molecular weight of 30.4 kDa.
Peptides & proteins
ATF-1
at -20°C
at least 12 months
NAME: Glial Derived Neurotrophic Factor; ACCESSION/UNIPROT#: P39905; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, 100 mM sodium chloride, pH 4.0. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: C6 cell proliferation with an acceptance criteria of 3 ug/mL (ED50), 3.3 x 10^2 units/mg.; #AA: 270; SEQUENCE: MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI