IL-6, human recombinant
Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by T cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Rα and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells. Recombinant human IL-6 is a non-glycosylated protein.
Peptides & proteins
IFN-β2, B-cell Differentiation Factor, BSF-2, HSF, MGI-2
at -20°C
at least 12 months
NAME: Interleukin-6; ACCESSION/UNIPROT#: P05231; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile 10 mM HCI at 0.1 mg/mL.; TESTING: 7TD1 cell proliferation with an acceptance criteria of 250 pg/mL (ED50), 4 x 10^6 units/mg.; #AA: 185; SEQUENCE: MPVPPGEDSK DVAAPHRQPL TSSERIDKQI RYILDGISAL RKETCNKSNM CESSKEALAE NNLNLPKMAE KDGCFQSGFN EETCLVKIIT GLLEFEVYLE YLQNRFESSE EQARAVQMST KVLIQFLQKK AKNLDAITTP DPTTNASLLT KLQAQNQWLQ DMTTHLILRS FKEFLQSSLR ALRQM