IWP-2 is an inhibitor of Wnt processing and secretion. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem cells.
Product Type:
Peptides & proteins
CAS Number:
686770-61-6
Alternative Names:
Inhibitor of WNT Production-2, N-€‹(6-€‹methyl-€‹2-€‹benzothiazolyl)-€‹2-€‹[(3,€‹4,€‹6,€‹7-€‹tetrahydro-€‹4-€‹oxo-€‹3-€‹phenylthieno[3,€‹2-€‹d]pyrimidin-€‹2-€‹yl)thio]-€‹acetamide
Storage Temperature:
at -20°C
Shelf Life:
at least 12 months