BDS-1
BDS-I is a selective blocker of Kv3.4 channel. BDS-1 is a 43 amino acid peptide which was originally isolated from the venom of the sea anemona Anemonia Viridis. BDS-1 is a highly selective blocker of the voltage-gated potassium channel Kv3.4/ KCNC4 expressed in various tissues (purkinje, vascular smooth muscle cells). The reversible blockage is rapid and direct. It was observed that BDS-1 also slows the inactivation of the heteromeric Kv3.4/Kv3.1 and homomeric Kv3.1 and Kv3.2.
- Applications:Potassium channel blocker
Peptides & proteins
1) Diochot et al (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J.Biol.Chem. PMID: 9506974.; 2) Pannaccione et al (2007) Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol.Pharmacol. PMID: 17495071.; 3) Martina M., et al. (2007) Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J. Neurophysiol. PMID: 17065256.
Stable at room temperature under lyophilized powder. Store at -20°C for long term storage over 2 mon
AA sequence: Ala-Ala-Pro-Cys4-Phe-Cys6-Ser-Gly-Lys-Pro-Gly-Arg-Gly-Asp-Leu-Trp-Ile-Leu-Arg-Gly-Thr-Cys22-Pro-Gly-Gly-Tyr-Gly-Tyr-Thr-Ser-Asn-Cys32-Tyr-Lys-Trp-Pro-Asn-Ile-Cys39->Cys40-Tyr-Pro-His-OH; Disulfide bonds: Cys4-Cys39, Cys6-Cys32, Cys22-Cys40