Clodronate 2Na
Induces osteoclast apoptosis / Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2
Biochemicals & reagents
88416-50-6
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945 2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255
-20°C
PATHWAY: Mitochondrial function; Apoptosis inducer; Cytotoxicity -- RESEARCH AREA: Cell death -- DISEASE AREA: Osteoporosis