C22 Ceramide
Mitochondrial lipid messenger / A long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2
Biochemicals & reagents
86950-30-4
1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539 2) Goldenberg et al. (2016), Acyl CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1
-20°C
PATHWAY: Mitochondrial function; Sphingolipid metabolism -- RESEARCH AREA: Cellular stress -- DISEASE AREA: Heart disease