TAME
Supplier:
Catalogue number:
10-1364-02
Size:
500 mg
Product is available in:
Ub-ligase inhibitor / TAME binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2
Product Type:
Biochemicals & reagents
CAS Number:
1784-03-8
Reference:
1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage Cancer Cell 18 382 / 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination Nat.Chem.Biol. 8 383
Storage Temperature:
-20°C
Additional Information:
TARGET: Ubiquitin ligase -- PATHWAY: Degradation; Posttranslational modification -- RESEARCH AREA: Ubiquitin/Proteasome