Nutlin-3
p53/mdm2 inhibitor / MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p531. Displays antiproliferative activity and induces apoptosis in a variety of tumor cells2-4.
Biochemicals & reagents
548472-68-0
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2..; Science, 303 844. / 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neuroscie. Lett., 513 106 / 3) Manfe et al. (2012), MDM2 inhibitor nutlin-31 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 / 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
-20°C
TARGET: Transcription factor -- PATHWAY: Cell cycle; Apoptosis inducer; p53; Proliferation; Transcription -- RESEARCH AREA: Cell death; Stem cells -- DISEASE AREA: Cancer