10058-F4
Myc inhibitor / Effectively disables c-Myc by inhibiting the c-Myc-Max associationn and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells2. Induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia3. Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells4.
Biochemicals & reagents
403811-55-2
1) Yin et al. (2003), Low molecular weight inhibitors of Myc-Max interaction and function; Oncogene, 22 6151 2) Lin et al. (2007), Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells; Anti-Cancer Drugs, 18 161 3) Huang et al. (2006), A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia; Exp. Hematol., 34 1480 4) Zirath et al. (2013), MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells; Proc. Natl. Acad. Sci. USA, 110 10258
RT
TARGET: Transcription factor -- PATHWAY: Cell cycle; DNA damage; Apoptosis inducer; Transcription; Myc -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer