JNJ-1661010
Supplier:
Catalogue number:
10-1298-01
Size:
10 mg
Product is available in:
FAAH inhibitor / Potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. Displays analgesic activity in various animal models.
Product Type:
Biochemicals & reagents
CAS Number:
681136-29-8
Alternative Names:
N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Reference:
1) Karbarz et al. (2009), Biochemical and biological properties of 4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase; Anesth. Analg., 108 316
Storage Temperature:
-20°C
Additional Information:
TARGET: Serine hydrolase -- PATHWAY: Cannabinoid receptor; Fatty acid metabolism -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain