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ML60218

Supplier:
Catalogue number:
10-1481-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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RNA Polymerase III inhibitor / A broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 μM and 27 μM respectively.1 Combined treatment with ML60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2

Product Type:

Biochemicals & reagents

CAS Number:

577784-91-9

Alternative Names:

RNA Polymerase III inhibitor

Reference:

1) Wu et al. (2003), Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell, 2 256 2) Yee et al. (2012), Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open, 1(4) 295

Storage Temperature:

RT

Additional Information:

TARGET: RNA -- PATHWAY: Transcription; Apoptosis inducer -- RESEARCH AREA: Cell death