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Chaetocin

Supplier:
Catalogue number:
10-2404-01
Size:
200 ug
Product is available in:
  • USA
  • Canada
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Lys methyltransferase inhibitor / Antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis2.

Product Type:

Biochemicals & reagents

CAS Number:

28097-03-2

Reference:

1) Greiner et al. (2005), Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9; Nat. Chem. Biol., 1 143. / 2) Isham et al. (2007), Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress; Blood, 109 2579

Storage Temperature:

-20°C

Additional Information:

TARGET: Protein methyltransferase -- PATHWAY: Chromatin; Apoptosis inducer; Posttranslational modification -- RESEARCH AREA: Epigenetics; Cell death; Cellular stress; Oxidative stress -- DISEASE AREA: Cancer; Infectious disease