Chaetocin
Lys methyltransferase inhibitor / Antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis2.
Biochemicals & reagents
28097-03-2
1) Greiner et al. (2005), Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9; Nat. Chem. Biol., 1 143. / 2) Isham et al. (2007), Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress; Blood, 109 2579
-20°C
TARGET: Protein methyltransferase -- PATHWAY: Chromatin; Apoptosis inducer; Posttranslational modification -- RESEARCH AREA: Epigenetics; Cell death; Cellular stress; Oxidative stress -- DISEASE AREA: Cancer; Infectious disease