Ilomastat (GM-6001)
MMP inhibitor / Potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19.
Biochemicals & reagents
142880-36-2
GM-6001
1) Saghatelian, et al. (2004) Activity-based probes for the proteomic profiling of metalloproteases Proc. Natl. Acad. Sci. USA 101 10000 / 2) Galardy et al.(1994) Low molecular weight inhibitors in corneal ulceration, Ann.N.Y.Acad.Sci 732 315 / 3) Yamamoto et al.(1998) Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket, J. Med. Chem. 41 1209 / 4) Park et al. (2003) The intermediate S1’ pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling J. Biol. Chem. 278 51646
-20°C
TARGET: Protease -- DISEASE AREA: Cancer; Inflammation