Actinonin
Leucyl aminopeptidase inhibitor / A potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Also inhibits peptide deformylase.2 Induces apoptosis and displays antitumor activity in vivo.3 Inhibits neutrophil collagenase and other MMPs.4 Induces mitochondrial proteotoxicity.5
Biochemicals & reagents
13434-13-4
1) Hachisu et al. (1987), Analgesic effect of actinonin, a new potent inhibitor of multiple encephalin degrading enzymes; Life Sci., 41 235 2) Lee et al. (2004), Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics; J. Clin. Invest., 114 1107 3) Xu et al. (1998), Antitumor activity of actinonin in vitro and in vivo; Clin. Cancer Res., 4 171 4) Sina et al. (2009), Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated pro-MMP-2 activation; Cancer Lett., 279 171 5) Burman et al. (2017) Mitochondrial fission facilitates the selective mitophagy of protein aggregates; J. Cell. Biol., 216 3231
-20°C
TARGET: Protease -- PATHWAY: Apoptosis inducer; Degradation; Mitophagy; Mitochondrial function -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer