Okadaic acid
Protein phosphatase PP2A inhibitor / A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation2. Induces apoptosis in a variety of cell types3. Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes4. Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.
Biochemicals & reagents
78111-17-8
NSC 677083
1) Cohen et al. (1990), Okadaic acid: a new probe for the study of cellular regulation; Trends Biochem. Sci., 15 98 2) Hardie et al. (1991), Use of okadaic acid to inhibit protein phosphatases in intact cells; Clin. Methods Enzymol., 201 469 3) Haneji et al. (2013), Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells; J. Oncol., 42 1904 4) Standaert et al. (1999), Okadaic acid activates atypical protein kinase C (zeta/lambda) In rats and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport; J. Biol. Chem, 274 14074
-20°C
TARGET: Phosphatase -- PATHWAY: Apoptosis inducer; Cell cycle; Apoptosis inhibitor -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer