3-Aminobenzamide
PARP inhibitor / Inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. Protects cells from oxygen radical and nitric oxide toxicity4.
Biochemicals & reagents
3544-24-9
3-AB; INO-1001
1) Purnell and Whish et al. (1980), Novel inhibitors of poly(ADP-ribose) synthetase; Biochem. J., 185 775 2) Kuo et al. (1996), Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells; Biochem. Biophys. Res. Commun., 219 502 3) Malorni et al. (1995), 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion; Biochem. Biophys. Res. Commun., 207 715 4) Heller et al. (1995), Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells; J. Biol. Chem., 270 11176
RT
TARGET: PARP -- PATHWAY: DNA repair; Apoptosis inhibitor -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Cancer