STF-62247
Autophagy inducer / Specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable
Biochemicals & reagents
315702-99-9
1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944 / 2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987 / 3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388
RT
TARGET: Lysosome -- PATHWAY: Autophagy; Fatty acid metabolism; Glucose metabolism; Amino acid metabolism; Redox -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Cancer