KT-5720
PKA inhibitor / Potent selective protein kinase A inhibitor: PKA (Ki = 60 nM). Displays no effect on PKC or PKG (Ki > 20 µM)1. Inhibits axon branching in cultured embryonic rat hippocampal pyramidal neurons2. Cell permeable.
Biochemicals & reagents
108068-98-0
1) Kase et al. (1987), K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Cabell et al. (1993), Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons; Int. J. Dev. Neurosci., 11 357
-20°C
TARGET: Kinase -- RESEARCH AREA: Neuroscience