LH-846
Supplier:
Catalogue number:
10-1465-01
Size:
5 mg
Product is available in:
Casein kinase 1δ inhibitor / Potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1
Product Type:
Biochemicals & reagents
CAS Number:
639052-78-1
Reference:
1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylationof the period protein; Agnew Chem. Int. ed. Engl., 50 10608
Storage Temperature:
RT
Additional Information:
TARGET: Kinase -- RESEARCH AREA: Circadian clock