XMU-MP-1
Potent and selective MST1/2 kinase inhibitor / XMU-MP-1 is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.
Biochemicals & reagents
2061980-01-4
1) Fan et al. (2016), Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration; Sci. Transl. Med. 8 352ra108 2) Qu et al. (2018); MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-kB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice, Behav. Neurol., 2018 6470957 3) Triastuti et al. (2019), Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload; Br. J. Pharmacol. 176 3956 4) Liu et al. (2022), XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway; Eur. J. Pharmacol. 919 174801
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TARGET: Kinase -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Ischemia; Inflammation