Antioxidant / Water soluble derivative of vitamin E with potent antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3 Attenuates impaired proliferation of oxidatively stressed myoblasts overexpressing parkin interacting substrate (PARIS/ZNF746).4 Frequently employed as a benchmark compound to compare the antioxidant capacity of other compounds5 and reference standard for determination of “trolox equivalents”6.
Biochemicals & reagents
53188-07-1
1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Salgo and Pryor (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482 4) Bae et al. (2020), ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts; Cell Death Dis., 11 359 5) Muñoz et al. (2020), Contribution to determining the antioxidant capacity of melatonin in orodispersible tablets - comparison with reference antioxidants; Arch Med. Sci., 16 871 6) Re et al. (1999), Antioxidant activity applying an improved ABTS radical cation decolorization assay; Free readic. Biol. Med., 26 1231
RT
TARGET: Antioxidant -- PATHWAY: Redox; Apoptosis inhibitor; Cytokine; NFkappaB -- RESEARCH AREA: Cell death; Cellular stress; Neuroscience; Oxidative stress -- DISEASE AREA: Neurodegeneration