NFκB activation inhibitor / Antioxidant. Inhibits NFκB activation and the growth of transformed cells. Inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable.
Biochemicals & reagents
104594-70-9
Caffeic acid phenethylester
1) Sud’ine, et al. (1993) Caffeic scid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 21 329 / 2) Natarajan, et al., (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. USA 93 9090 / 3) Chiao, et al. (1995). Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res. 55 3576 / 4) Orban et.al. (2000), Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunimodulation 7, 99
RT
TARGET: Antioxidant -- PATHWAY: Redox; NFkappaB; Apoptosis inducer; Proliferation; Cytokine -- RESEARCH AREA: Cell death; Immunology -- DISEASE AREA: Cancer; InflammationObesity