Myriocin (ISP-1)
Blocks sphingolipid biosynthesis / Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3
Biochemicals & reagents
35891-70-4
ISP-1
1) Fujita et al.(1994) Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite J. Antibiot. 47 208 / 2) Miyake, et al.,(1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211 396 / 3) Lee et al. (2012) Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis Cancer Biol Ther. 13 92
-20°C
TARGET: Antibiotic -- PATHWAY: Cell Cycle; Sphingolipid metabolism; Posttranslational modification; Proliferation; p53; Apoptosis inducer -- RESEARCH AREA: Immunology; Cell death -- DISEASE AREA: Cancer; Infectious disease