Methoprene Acid
RXR agonist / Methoprene acid (53092-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator in both insect and mammalian cells with no activity at RAR.1 Negatively regulates thrombosis and hemostasis.2 Induces neurosteroid biosynthesis in human glial GI-1 cells.3 Increases the expression of the brown-fat-uncoupling-protein-1 gene (ucp-1).4
Biochemicals & reagents
53092-52-7
1) Harmon et al. (1995), Activation of mammalian retinoid X receptors by the insect growth regulator methoprene; Proc. Natl. Acad. Sci. USA, 92 6157 2) Unsworth et al. (2017), RXR Ligands Negatively Regulate Thrombosis and Hemostasis ; Arterioscler. Thromb. Vasc. Biol., 37 812 3) Kushida and Tamura (2009), Retinoic acids induce neurosteroid biosynthesis in human glial GL-1 cells via the induction of steroidogenic genes; J. Biochem., 146 917 4) Alvarez et al. (2000), Both retinoic-acid-receptor and retinoid-X-receptor-dependent signaling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids; Biochem. J., 345 Pt 1 91
-20°C
TARGET: Retinoid receptor and related; Transcription factor -- PATHWAY: Transcription -- RESEARCH AREA: Neuroscience