Oltipraz
Nrf2 activator / Upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis2. Attenuates chronic hypoxia-induced cardiopulmonary alterations in mice3. Promotes liver regeneration after partial hepatectomy4. Off target effects: Activates constitutive androstane receptor (CAR)5.
Biochemicals & reagents
64224-21-1
1) Yu et al. (2011), Olipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice ; Diabetological, 54 922 2) Shimozono et al. (2013), Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model; Mol. Pharmacol, 84 62 3) Eba et al. (2013), The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice; Am. J. Respir. Cell. Mol. Biol., 49 324 4) Cho et al. (2009), Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kianse dependent C/EBPbeta and cyclin E regulation; Arch. Pharm. Res., 32 625 5) Merrell et al. (2008), The Nrf2 activator oltipraz also activates the constitutive androstane receptor; Drug Metab. Dispos., 36 1716
-20°C
TARGET: Cytochrome/MDR; Transcription factor -- PATHWAY: Redox; Transcription; Ferroptosis -- RESEARCH AREA: Oxidative stress; Cell death -- DISEASE AREA: Cancer; DiabetesObesity; Liver disease