Hydroxyurea
Anticancer agent / Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair.1,2 Reduces cell proliferation, and causes S-phase arrest and death.3 Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA.4 Stimulates fetal hemoglobin production in vitro and in vivo.5 Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering.6 Anticancer and antiviral agent.
Biochemicals & reagents
127-07-1
Hydroxycarbamide
Gräsland et al. (1985), The tyrosyl free radical in ribonucleotide reductase; Health Perspect., 64 139 Yarbro (1992), Mechanism of action of hydroxyurea; Oncol., 3 (Suppl 9) 1 Singh and Xu (2016), The Cell Killing Mechanisms of Hydroxyurea; Genes (Basel), 7 99 Campbell et al. (2021), Temporal modulation of the NF-kB Re1A network in response to different types of DNA damage; J., 478 533 Baliga et al. (2000), Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors; J. Hematol., 65 227 Kwak et al. (2021), Hydroxyurea selection for enhancement of homology-directed targets integration of transgenes in CHO cells; Biotechnol, 62 26
-20°C
TARGET: DNA; RNA -- PATHWAY: Transcription; Cell cycle; DNA repair; DNA synthesis; NFkappaB -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Cancer