Norquetiapine · 2HCl
Quetiapine metabolite / Pharmacologically active metabolite of quetiapine.1 Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2 Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3 Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Biochemicals & reagents
111974-74-4
1) Altamura et al. (2012), Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig., 32 213 2) Lopez Munoz and Alamo et al. (2013), Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry, 4 102 3) Di. Benedetto et al. (2012), N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology, 62 209 4) Bjorkholm et al. (2013), Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol., 23 709
RT
TARGET: Monoamine transporter; Norepinephrine -- PATHWAY: ERK -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Mood disorders