Huperzine A
Acetylcholinesterase inhibitor / Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors (IC50 rat cerebral cortex = 126 µM)2. It is thought to have cognitive-enhancing properties, including amelioration of Alzheimer’s disease.3,4 Recently, it has also been shown to rescue ovarian function in rats5 as well as display analgesic activity in a rat spinal cord compression model6.
Biochemicals & reagents
102518-79-6
(-)-Huperzine A; (-)-Selagine
1 Zhao and Tang (2002), Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine; Eur. J. Pharmacol., 455 101 2 Zhang and Hu (2001), Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons; Neuroscience, 105 663 3 Zangara (2003), The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease; Pharmacol. Biochem. Behav., 75 675 4 Qan et al. (2020), Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer’s disease; Drug Deliv., 27 1147 5 Riquelme et al. (2020), Huperzine-A administration recovers rat ovary function after sympathetic stress; Neuroendocrinol., e12914 6 Yu et al. (2013), Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A; Proc. Natl. Acad. Sci. USA, 110 E746
-20°C
TARGET: Acetylcholinesterase/Butyrylcholinesterase; Ion channel -- PATHWAY: ACh (Acetylcholine) signaling; Apoptosis inhibitor -- RESEARCH AREA: Neuroscience; Cell death -- DISEASE AREA: Neurodegeneration; Pain