Lomerizine
Calcium channel blocker / Lomerizine is a clinically useful calcium channel blocker (L and T-type). It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A antagonistic effects.1 Lomerizine also displays anti-glaucoma effects via an increase in ocular circulation and protection of neuronal cells against retinal neurotoxicity with minimal cardiovascular effects.2 Lomerizine has also shown various other neuroprotective properties.3,4,5,6
Biochemicals & reagents
101477-54-7
KB-2796
1) Ishii et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery; J.Pharmacol.Sci. 111 221 2) Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199 3) Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol.Cell Biochem. 358 1 4) Savigni et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma; Neuropharmacology 75 380 5) Tran et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43; J.Neurochem. 130 455 6) O’Hare et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro; Neuroscience 339 450
-20°C
TARGET: Ion channel; GPCR -- PATHWAY: Calcium signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain