Clozapine (base)
Dopamine D2/D4 antagonist / Dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4
Biochemicals & reagents
5786-21-0
1) Seeman and Van Tol (1994), Dopamine receptor pharmacology; Trends Pharmacol. Sci., 15 264 2) Ellenbroek et al. (1991), The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine Eur. J. Pharmacol., 196 103 3) Canton et al. (1990), Binding of the typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites; Eur. J. Pharmacol., 191 93 4) Kuoppamaki et al. (1993), clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists; Eur. J. Pjharmacol., 245 179
RT
TARGET: Dopamine; GPCR -- RESEARCH AREA: Neuroscience