VAS-2870
Nox inhibitor / NAD(P)H oxidase (Nox) inhibitor. Abolishes PDGF-mediated Nox activation and ROS production (100% at 10 uM). Inhibits PMA-induced oxidative burst in HL-60 cells (IC50=2 µM). Enhances TGF-ß-induced apoptosis in liver tumor cells.
Biochemicals & reagents
722456-31-7
1) Freyhaus et al., (2006), Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation; Cardiovasc. Res. 71 331 / 2) Stielow et al., (2006), Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells; Biochem. Biophys. Res. Commun. 344 200 / 3) Sancho et al., (2011), The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells; Biochem. Pharmacol. 81 917
RT
TARGET: Nox (NADH/NADPH oxidase); Energy production -- PATHWAY: TGF-beta; Apoptosis inducer; NAD, NADP pathways -- RESEARCH AREA: Oxidative stress; Cell death -- DISEASE AREA: Inflammation; Ischemia