MK-571
CysLT1 antagonist / Potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist(LTD4)1 displaying inverse agonist activity2, Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes. Selective for the CysLT1 receptor. Multidrug resistance protein 1 (MRP1) inhibitor.3
Biochemicals & reagents
115104-28-4
L-660711
1) Jones, et al . (1989) Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.; Can. J. Physiol. Pharmacol. 67, 17 / 2) Dupre et al (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102 / 3) Vellenga et al (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 127 441
RT
TARGET: Leukotriene receptor; Cytochrome/MDR -- PATHWAY: Lipid signaling; Calcium signaling -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation