Stimulates pancreatic beta-cell proliferation / Stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both α- and β-cell proliferation.2 May lead to the development of new therapeutics for diabetes.3 Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression.4 Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells.5 Cell permeable.
Biochemicals & reagents
1421227-53-3
1 Shen et al. (2013), Small-molecule inducer of ß cell proliferation identified by high throughput screening; J. Am. Chem. Soc., 135 1669 2 Boerner et al. (2015), WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability; Endocrinol. J., 62 379 3 Shirakawa and Kulkarni (2016), Novel factors modulating human ß-cell proliferation; Diabetes Obes. Metab, 18 Suppl. 1 71 4 Zhang et al. (2021), WS6 Induces Adult Hippocampal Neurogenesis in Correlation to its Antidepressant Effect on the Alleviation of Depressive-like Behavior of Rats; Neuroscience 473 119 5 Hu et al. (2022), Induction of mouse totipotent stem cells by a defined chemical cocktail; Nature, Online ahead of pub
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TARGET: Ribosome; Transcription factor; RNA -- PATHWAY: NFkappaB; Transcription -- RESEARCH AREA: Stem cells; Neuroscience -- DISEASE AREA: Diabetes; Mood disorders