Streptozotocin
Diabetes inducer / An N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase.3 Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition.4 Is not a spontaneous NO donor.5
Biochemicals & reagents
18883-66-4
Streptozocin; U-9889
1) Szkudelski et al. (2001), The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.; Physiol. Res., 50 537 2) Bennett & Pegg (1981), Alkylation of DNA in rat tissues following administration of streptozotocin; Cancer Res., 41 2786 3) Konrad et al. (2001), The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase; Biochem. J., 356 Pt 1 31 4) Gao et al. (2000), Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells; Arch. Biochem. Biophys., 383 296 5) Kroncke & Kolb-Bachofen (1996), Streptozotocin is not a spontaneous NO donor.; Free Radic. Res., 24 77
-20°C
TARGET: DNA; Antibiotic; Glycosylation -- PATHWAY: Apoptosis inducer; Cell cycle; DNA damage; Glycation -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Diabetes; CancerInfectious disease; Inflammation