ω-conotoxin MVIIC
ω-conotoxin MVIIC has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
Peptides & proteins
147794-23-8
omega conotoxin MVIIC
Farr-Jones, S., et al. (1995) J Mol Biol; Hillyard, D. R., et al. (1992) Neuron; Kim, J. I., et al. (1995) Biochem Biophys Res; Nielsen, K. J., et al. (1999) J Mol Biol
RT