Spike S protein library

Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. The S1 subunit allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry. Spike (S) is a glycoprotein of 1 273 aa length. This library is made of 316 peptides with a length of 15 amino acids and an overlap of 11 amino acids without post-translational modificaton.