Kinase Inhibitors & Modulators

(5Z)-7-Oxozeaenol    (TAK1 inhibitor)

3-Methyladenine    (Autophagosome inhibitor)

6BIO    (GSK-3 inhibitor)

7,8-Dihydroxyflavone    (TrkB agonist/neurotrophic)

7-Cl-O-Nec1    (Rip1 blocker)

A-769662    (AMPK activator)

A83-01    (ALK inhibitor)

AAL-993    (VEGFR inhibitor)

Abemaciclib    (CDK 4/6 inhibitor)

ABT-869    (Dual VEGFR and PDGFR kinase inhibitor)

Acalabrutinib    (BTK inhibitor)

Adavosertib    (Wee1 kinase inhibitor)

Afatinib    (EGFR and HER2 inhibitor)

AG 1478 (Base)    (EGFR kinase inhibitor)

AG-1296    (PDGFR kinase inhibitor)

AG-1517 · HCl    (Tyrosine kinase inhibitor)

AG-490    (JAK-2 inhibitor)

AG-879    (NGFR kinase inhibitor)

AICAR    (AMPK activator)

Alectinib    (ALK inhibitor)

Alisertib    (Aurora A inhibitor; Destablizes Myc)

Alsterpaullone    (GSK3β inhibitor, CDK5/p25 inhibitor)

Amlexanox    (TBK1 inhibitor / Antidiabetic)

ANA-12    (TrkB antagonist)

Anisomycin    (Anoikis sensitizer)

Apigenin    (Protein kinase inhibitor)

Apilimod    (IL/12 and 23/PIKfyve inhibitor)

AR-A 014418    (GSK-3 inhibitor)

AS-041164    (PI 3-Kγ inhibitor)

AS-605240    (PI 3-Kinase inhibitor)

Auranofin    (IKK inhibitor)

Autophinib    (Autophagy inhibitor)

Axitinib    (VEGFR kinase inhibitor)

AZ20    (ATR Kinase inhibitor)

AZ3146    (Msp1 kinase inhibitor)

AZD1152-HQPA    (Aurora B kinase inhibitor)

AZD1208    (pan-PIM kinase inhibitor)

AZD6244    (ERK inhibitor)

AZD7648    (DNA-PK inhibitor/CRISPR enhancer)

AZD7762    (Checkpoint kinase 1/2 inhibitor)

AZD8055    (mTOR kinase inhibitor)

Baicalein    (Inhibitor of protein tyrosine kinase in leukemia (CEM cells))

Baricitinib    (JAK 1/2 inhibitor)

BAY 11-7082    (IKK inhibitor)

Beauvericin    (Disrupts mitochondrial volume)

Belumosudil    (ROCK2 inhibitor)

BI-D1870    (p90 Ribosomal S6 kinase inhibitor)

Binimetinib    (MEK1/2 inhibitor)

BML-259    (CDK5/p25 inhibitor)

BML-277    (CHK2 inhibitor)

BML283    (PKM2 activator)

Bosutinib    (Dual Src/Abl kinase inhibitor)

BRD-7389    (p90 RSK inhibitor: insulin stimulator)

Brigatinib    (pan-ALK inhibitor)

BT2    (BCKDC kinase inhibitor)

Buparlisib    (PI3-kinase inhibitor)

BX-795    (Dual TBK1/IKKε inhibitor)

C16    (PKR inhibitor)

C8-Ceramide    (Protein kinase activator)

Cabozantinib    (Met and VEGFR2 inhibitor)

Calphostin C    (Protein Kinase C inhibitor)

CBR-470-1    (NRF2 signaling activator)

CDDO-Me    (Nrf2 activator)

Cercosporin    (ROS-generating fungal toxin)

CHIR-99021    (GSK3β inhibitor)

Chroman 1    (ROCK II inhibitor / Stem cell cytoprotectant)

CID-2011756    (PKD inhibitor)

CR8 3HCl (R)    (CDK inhibitor)

Crenolanib    (PDGFR and FLT3 inhibitor)

Crizotinib    (c-Met and ALK inhibitor)

CUDC-101    (Dual HDAC and EGFR inhibitor)

CZC-54252    (LRRK2)

CZC-8004    (Multi-kinase inhibitor; affinity ligand)

Dabrafenib    (B-Raf mutant inhibitor)

Damnacanthal    (p56 Lck inhibitor)

Dasatinib    (Src and Bcr/Abl inhibitor)

Defactinib    (FAK inhibitor)

Deguelin    (Akt inhibitor)

Dibutyryl-cAMP    (Cell permeable cAMP)

Dihydrosphingosine    (PKC inhibitor, Sphingosine precursor)

DMPQ 2HCl    (PDGFRβ inhibitor)

Doramapimod    (p38 MAPK inhibitor)

Dorsomorphin    (AMPK inhibitor)

Dovitinib    (Kinase inhibitor)

DRB    (Transcription inhibitor, CK2 inhibitor)

Dubermatinib    (AXL inhibitor)

Duvelisib    (PI3K δ/γ inhibitor)

eFT508    (Potent MNK1/2 inhibitor)

Enzastaurin    (PKC inhibitor)

ERGi-USU    (ERG inhibitor)

Erlotinib · HCl    (EGFR Kinase inhibitor)

Everolimus    (mTOR inhibitor)

FAK inhibitor 14    (FAK inhibitor)

Fascaplysin    (CDK4 inhibitor)

Fasudil · HCl    (ROCK inhibitor)

Filgotinib    (JAK1 inhibitor)

Flavopiridol HCl    (CDK inhibitor)

Fruquintinib    (VEGFR kinase inhibitor)

FSC-231    (PICK1 PDZ domain inhibitor)

Galunisertib    (TGFß receptor 1 inhibitor / Cancer immunotherapeutic)

GDC-0941    (pan-PI3K inhibitor)

Gefitinib    (EGFR-Kinase inhibitor)

Genistein    (Tyrosine kinase inhibitor)

GF-109203X    (PKC inhibitor)

Gilteritinib    (FLT3 inhibitor)

Glumetinib    (Highly selective c-Met inhibitor)

GO289    (Casein kinase 2 inhibitor)

Go-6983    (PKC inhibitor)

GSK2334470    (Potent and selective PDK1 inhibitor)

GSK2606414    (PERK inhibitor)

GSK2636771    (Selective PI3Kß inhibitor)

GSK2656157    (Potent and selective PERK inhibitor)

GSK2982772    (RIP1 inhibitor)

GSK583    (RIP2 kinase inhibitor)

GSK-690693 HCl    (AKT inhibitor)

GSK8612    (Highly selective TBK1 inhibitor)

GSK872    (Necroptosis inhibitor / RIP3 inhibitor)

GW-2580    (cFMS kinase inhibitor)

GW-441756    (NGFR kinase inhibitor)

GW-5074    (c-Raf1 inhibitor)

GW788388    (TGF-ß receptor kinase inhibitor)

H89 · 2HCl    (PKA inhibitor)

HA-100 2HCl    (Multi-kinase inhibitor)

Herbimycin A    (Src inhibitor)

Hypericin    (Protein kinase C inhibitor)

Hypothemycin    (MEK inhibitor)

Ibrutinib    (BTK inhibitor)

ID-8    (DYRK inhibitor)

Idelalisib    (Selective PI3Kδ inhibitor)

IM-12    (GSK-3ß inhibitor)

IM156    (AMPK activator/Mitochondrial protein complex I inhibitor)

Imatinib mesylate    (BCR-ABL inhibitor)

Indirubin-3'-monoxime    (GSK-3b and CDK inhibitor)

Indolactam V    (PKC activator; stem cell inducer)

Ingenol-3-angelate    (PKC activator)

INK-128    (TORC1/2 inhibitor)

IPA-3    (PAK1 inhibitor)

Ipatasertib    (Pan-AKT inhibitor)

IPI-549    (PI3Kγ inhibitor)

IQ-1S    (JNK3 inhibitor)

IWP-4    (Porcn inhibitor: Wnt/Beta-catenin pathway inhibitor)

JNK inhibitor IX    (JNK inhibitor)

JNK-IN-8    (JNK inhibitor)

JX-401    (p38a MAP kinase inhibitor)

K252A    (Kinase inhibitor (pan-specific))

K252B    (Kinase inhibitor (pan-specific))

Kenpaullone    (GSK-3ß/CDK/KLF4 inhibitor)

Ki8751    (VEGFR2 inhibitor)

KT-5720    (PKA inhibitor)

KT-5823    (PKG inhibitor)

KU-55933    (ATM Kinase inhibitor)

KW-2449    (Multikinase inhibitor)

Lapatinib (base)    (EGFR and HER2 inhibitor)

Larotrectinib    (panTRK inhibitor)

LDC1267    (Selective inhibitor of TAM kinases)

LDN-192960 HCl    (Haspin and DYRK2/3 inhibitor)

LDN-193189 HCl    (ALK2 / ALK3 inhibitor)

Leelamine HCl    (Intracellular cholesterol inhibitor)

Lenvatinib    (VEGFR kinase inhibitor)

Lestaurtinib    (FLT3/ TrkA inhibitor)

LFM-A13    (BTK inhibitor)

LH-846    (Casein kinase 1δ inhibitor)

Linsitinib    (IGF-1R kinase / InsR kinase inhibitor)

LM22A-4    (TrkB agonist)

Locostatin    (RKIP/Raf-1 kinase disruptor)

LY2090314    (Wnt/ß-Catenin pathway activator / GSK-3 inhibitor)

LY2603618    (Chk1 inhibitor)

LY294002    (PI 3-Kinase inhibitor)

LY364947    (ALK5 inhibitor)

LYS6K2    (S6K inhibitor)

MBQ-167    (Rac/Cdc42 inhibitor)

Meleagrin    (Met inhibitor; Anticancer activity)

MHY1485    (mTOR activator)

Mitapivat    (Pyruvate kinase activator)

MK-2206    (Potent and selective AKT inhibitor)

ML167    (Clk4 inhibitor)

N,N-Dimethylsphingosine    (Sphingosine kinase inhibitor)

Necrostatin-1    (Necroptosis inhibitor)

Necrostatin-34    (RIP1 kinase inhibitor)

Necrosulfonamide    (Necroptosis inhibitor / MLKL inhibitor)

Nelfinavir mesylate    (HIV Protease inhibitor / Anticancer activity)

Neratinib    (Dual EGFR and HER2 inhibitor)

NG52    (Phosphoglycerate kinase 1 inhibitor)

NH125    (Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor)

Nicotinamide    (SIRT1 inhibitor/essential nutrient)

Nilotinib    (BCR-ABL inhibitor)

Nilvadipine    (Syk inhibitor and Ca channel blocker)

Nintedanib    (VEGFR, PDGFR and FGFR kinase inhibitor)

NPC-15437    (PKC inhibitor)

NQDI-1    (ASK1 inhibitor)

NSC33994    (JAK2 inhibitor)

NU7441    (DNA-PK inhibitor)

NVP-231    (Ceramide kinase inhibitor)

NVP-BEZ235    (PI 3-K and mTOR inhibitor)

NVP-BGJ398    (FGFR inhibitor (pan-spec))

Osimertinib    (Mutant EGFR kinase inhibitor)

P505-15    (Highly selective Syk inhibitor)

Palbociclib    (CDK4/CDK6 inhibitor)

Parthenolide    (IκB inhibitor)

Pazopanib    (Multi-receptor tyrosine kinase inhibitor)

PD 325901    (MEK inhibitor)

PD173074    (FGFR inhibitor)

PD-98059    (MEK inhibitor)

Pexidartinib    (CSF1R inhibitor)

PF-543 HCl    (Sphingosine kinase-1 inhibitor)

PF-670462 dihydrochloride    (Casein kinase 1δ/ε inhibitor)

Phorbol 12-myristate-13-acetate    (PKC activator)

PI-103    (PI3K, mTOR and DNA-PK inhibitor)

Piceatannol    (SIRT1 activator)

Picropodophyllotoxin    (IGF1R inhibitor)

PIT-1    (PH domain antagonist)

PKC-412    (Protein kinase inhib (pan spec.))

PLX-4032    (BRAF inhibitor)

PLX4720    (Mutant B-Raf inhibitor)

PLX5622    (Highly selective CSF1R inhibitor)

Ponatinib    (Bcr-Abl and multikinase inhibitor)

PP1    (Src family kinase inhibitor)

PP2    (Src family kinase inhibitor)

PP242    (Dual mTORC1/mTORC2 inhibitor)

Prostratin    (Promotes neuro-regeneration)

Pterostilbene    (Resveratrol analog)

Purvalanol A    (CDK inhibitor)

PX-866    (PI3-K inhibitor)

Pyridone 6    (pan-JAK inhibitor)

Quizartinib    (FLT3 inhibitor)

R428    (AXL inhibitor)

R-59022    (DAG Kinase inhibitor)

Radicicol    (HSP90 inhibitor)

Rapamycin    (mTOR inhibitor)

Rebastinib    (Bcl-Abl1 inhibitor)

RECTAS    (pre-mRNA splicing modulator)

RepSox    (TGFβR-1 / ALK5 inhibitor)

Reversine    (Reverses differentiated cells to multipotent stem cells)

Ribociclib    (CDK4/6 inhibitor)

RIPA-56    (RIP1 kinase inhibitor)

Ro 31-6045    (p70 S6 Kinase inhibitor)

Ro 31-8425 HCl    (PKC inhibitor)

RO-3306    (CDK1 inhibitor)

Roscovitine    (p34/cdc2 inhibitor)

Ruxolitinib    (JAK inhibitor)

Saracatinib    (Src family kinase inhibitor)

SB 202190    (p38 MAP kinase inhibitor)

SB 203580    (p38 MAP kinase inhibitor)

SB-216763    (GSK-3 inhibitor)

SB-431542    (ALK4,5 and 7 inhibitor)

SB-525334    (ALK5 (TGFβR1) inhibitor)

SBI-0206965    (ULK1 inhibitor)

SC-514    (IKK-2 inhibitor)

SC-79    (AKT activator)

Selonsertib    (ASK1 inhibitor)

Selpercatinib    (Potent and selective RET kinase inhibitor)

SGC-GAK-1    (Cyclin G Associated Kinase (GAK) inhibitor)

Sitravatinib    (Multikinase inhibitor / Immuno-oncology agent)

Smer-28    (Autophagy inducer)

SMI-4a    (PIM1 inhibitor)

SNS-314 mesylate    (Aurora kinase inhibitor)

Sorafenib (base)    (Raf-1 inhibitor (and other kinases))

SP-600125    (JNK inhibitor)

Sphingosine    (PKC inhibitor)

SR-3576    (JNK3 inhibitor)

Src-I1    (Src kinase inhibitor)

SRPIN340    (SRPK inhibitor)

Staurosporine    (Protein kinase inhibitor)

STO-609    (CAMKK inhibitor)

SU-1498    (VEGF R kinase inhibitor)

SU-4312    (VEGFR / PDGFR kinase inhibitor)

SU-5402    (FGFR Phosphorylation inhibitor)

SU9516    (CDK inhibitor (pan-specific))

Sunitinib malate    (VEGFR, PDGFR kinase inhibitor)

Teleocidin A1    (Non-phorbol ester PKC activator)

Tepotinib    (c-Met inhibitor)

TG003    (Clk family kinase inhibitor)

TGX-221    (Potent and selective PI3Kß inhibitor)

TH257    (Allosteric LIM kinase inhibitor)

Thiazovivin    (Induces stem cell generation)

THZ1    (CDK7 inhibitor)

Tofacitinib    (JAK inhibitor)

Torin 1    (mTOR inhibitor)

Tozasertib    (Aurora kinase inhibitor)

TPCA-1    (Selective inhibitor of IκB kinase 2 (IKK2))

Trametinib    (MEK inhibitor)

Tyrphostin 9    (PDGFR kinase inhibitor and Ox. phosphorylation inhibitor)

U0126    (Selective MEK1 and MEK2 inhibitor)

UH15-38·2HCl    (RIP3K inhibitor)

UPF-1069    (PARP-2 inhibitor)

URMC-099    (Mixed-lineage kinase 3 inhibitor)

Vacuolin-1    (PIKfyve inhibitor)

Vandetanib    (VEGFRK inhibitor)

Vatalanib 2HCl    (VEGFRK inhibitor)

VE-821    (ATR inhibitor)

Volasertib    (Polo-like Kinase 1 inhibitor)

VX-702    (p38α MAP kinase inhibitor)

WH-4-023    (Src family inhibitor)

WHI-P131    (JAK3 inhibitor)

WNK463    (WNK kinase inhibitor)

Wortmannin    (PI3K inhibitor)

WP1066    (JAK/STAT3 inhibitor)

XL413·HCl    (Cdc7 inhibitor/CRISPR enhancer)

XMU-MP-1    (Potent and selective MST1/2 kinase inhibitor)

Y-27632 dihydrochloride    (ROCK family kinase inhibitor)

ZM-306416    (VEGFR kinase inhibitor)

ZM-336372    (c-Raf inhibitor)

ZM-447439    (Aurora B kinase inhibitor)

ZSTK474    (PI 3-kinase inhibitor)