Myelin oligodendrocyte glycoprotein (MOG) is located on the external surface of myelin, a membranous component of the central nervous system (CNS) that forms the insulating lipid layer around neurons. The major MOG splicing variant (a1 transcript) encodes a transmembrane protein with an extracellular domain of an Ig variable (IgV) fold. MOG IgV domains from the same or different cells dimerize and contribute to the organization and maintenance of the myelin sheath in neurons.
The encepalitogenic T cells recognize MOG and its immunodominant epitopes (epitopes 1-22, 35-55 and 92-106 located at the dimer interface) as foreign antigens and cause the destruction of myelin (demyelination) leading to the clinical condition known as multiple sclerosis (MS). Recognition of the antigen takes place in the context of the trimolecular complex formed by HLA, MOGpeptides and TCR.
Products
Note: product availability depends on country - see product detail page.
Details | Cat number & supplier | Size | Price |
MOG (35-55) peptide, mouse SB023-1MG · sb-Peptide | SB023-1MG sb-Peptide |
1 mg |
$102.67
1 mg
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MOG (35-55) peptide, mouse SB023-5*1MG · sb-Peptide | SB023-5*1MG sb-Peptide |
5x1 mg |
$359.00
5x1 mg
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MOG (35-55) peptide, mouse SB023-2*5MG · sb-Peptide | SB023-2*5MG sb-Peptide |
2x5 mg |
$513.00
2x5 mg
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MOG (35-55) peptide, mouse SB023-5*10MG · sb-Peptide | SB023-5*10MG sb-Peptide |
5x10 mg |
$983.00
5x10 mg
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